William L. Hwang, MD, PhD is a Principal Investigator and Physician-Scientist at the Center for Systems Biology, Krantz Family Center for Cancer Research, and Department of Radiation Oncology at Massachusetts General Hospital (MGH) and Harvard Medical School (HMS) where he leads the Laboratory for Spatial and Systems Oncology and cares for patients with pancreatic cancerand other gastrointestinal malignancies. The Hwang laboratory is focused on studying tumor-stroma interactions in cancer at unprecedented resolution through the development and application of techniques in advanced microscopy, single-cell and spatial biology, and genetic engineering to patient-derived  specimens, stromal tumoroids, and mouse models. Dr. Hwang is particularly interested in elucidating the (1) mechanisms of the rapeutic resistance mediatedby cancer cell-stromal interactions in the tumor microenvironment; (2) cell state plasticity involved in tumorigenesis and therapeutic resistance; and (3) mechanisms of tumor-nerve interactions, which are remarkably important in the pathogenesis of many cancers but poorly understood. He serves as Translational Chair of the NRG Oncology GI011 Phase 3 cooperative trial, Associate Directorof the Radiation Biology & Research Program at the MGB Cancer Center, and Associate Member of the Broad Institute of MIT and Harvard. His research has resulted in more than 50 peer-reviewed publications in high-impact journal sincluding Nature, Cell, Nature Genetics, Cancer Cell, and Cancer Discovery, as well as several awards including the Martha Gray Prize for Excellence in Research, Seidman Prize for Outstanding Thesis, summa cum laude graduation honors from Harvard Medical School, MGH Clinical Research Award, William Shipley Research Award, ASCO/CCF Young Investigator Award, MIT Koch Institute Image Award, AACR NextGen Star, Burroughs Wellcome Fund Career Award for Medical Scientists, Pancreatic Cancer Action Network Career Development Award, 40 under 40 in Cancer – Rising Stars and Emerging Leaders, and Sir William Osler Young Investigator Award.