Programme
09:15 - 09:30
Registration
16:00 - 18:30
Champalimaud Auditorium
09:15 - 09:30
Welcome Reception
17:00 - 18:30
Amphitheater
Complex Pancreatic Cancer Surgery
Cancer Systems and spatial approaches
Coffee Break
World Pancreas Forum (WPF)*
Vision of Champalimaud Foundation
Clinical applications for molecular subtypes
Complication Management in Pancreatic Surgery
Lunch
09:15 - 09:30
Welcome Introduction
08:30 - 09:00
Champalimaud Auditorium
- João Silveira Botelho, Vice-President of the Champalimaud Foundation, Lisbon, Portugal
- Peter Bailey, Director of Translational Research of the Botton-Champalimaud Pancreatic Cancer Centre, Lisbon, Portugal
- Markus Büchler, Director of the Botton-Champalimaud Pancreatic Cancer Centre, Lisbon, Portugal
09:15 - 09:30
Targeting Oncogenes
09:00 – 11:00
Champalimaud Auditorium
Chairs:
- Andreas Trumpp, Heidelberg, Germany
- Faiyaz Notta, Toronto, Canada
- Laura Wood, Baltimore, USA
- Scott Lowe
09:00 - 09:20
Targeting KRAS-drivenPancreatic Cancer
Mariano Barbacid, Madrid, Spain
09:20 - 09:40
The effects of pan-RAS inhibition on models of pancreatic ductal adenocarcinoma
Kenneth Olive, Boston, USA
09:40 - 10:00
Targeting RAS in Pancreatic Cancer
Andrew Aguirre, Boston, USA
10:00 - 10:20
KRAS inhibitors: resistance mechanisms and combinations
Channing Der, North Carolina, USA
10:20 - 10:40
TBC
Mallikha Singh
09:15 - 09:30
Radiology / Diagnostics / Artificial Intelligence for PDAC
09:00 – 11:00
Botton Room
Chairs:
- Celso Matos, Lisbon, Portugal
- Christoph Springfeld, Heidelberg, Germany
- Kuirong Jiang, Nanjing, China
- Martin Loos, Heidelberg, Germany
09:00 - 09:20
Evidence-based Radiology
Carlos Bilreiro, Lisbon, Portugal
09:20 - 09:40
Radiology of the Pancreas: State of the Art
Göetz Richter, Stuttgart, Germany
09:40 - 10:00
Artificial Intelligence for Diagnosis
Dow Mu Koh, London, UK
10:00 - 10:20
Artificial Intelligence for Screening
TBC
10:20 - 10:40
Interventional Radiology: Collections
Hugo Rio-Tinto, Lisbon, Portugal
10:40 - 11:00
Interventional Radiology: Bleeding
De-Hua Chang, Luzern, Switzerland
09:15 - 09:30
Coffee Break
10:40 - 11:30
09:15 - 09:30
Invasion and Metastasis - Organotropism, Perineural Invasion, Venous Invasion
11:30 - 13:10
Champalimaud Auditorium
Chairs:
- Anirban Maitra, New York, USA
- David Ting, Boston, USA
- Kenneth Olive, Boston, USA
- Laura Soucek, Barcelona, Spain
11:30 - 11:50
Exploring metabolic pathways that promote metastatic pancreatic cancer
Sophie Vasseur, Marseille, France
11:50 - 12:10
Insights into liver versuslung metastatic tropism in pancreatic ductal adenocarcinoma
Rosalie Sears, Portland, USA
12:10 - 12:30
Molecular and functional analysis of PDAC innervating neurons
Andreas Trumpp, Heidelberg, Germany
12:30 - 12:50
Lineage restricted evolutionary patterns in PDAC
Giannicola Genovese, Houston, USA
12:50 - 13:10
Venous invasion
Laura Wood, Baltimore, USA
09:15 - 09:30
Surgery vs wait and see: PanNET and other rare malignancies
11:30 - 13:30
Botton Room
Chairs:
- Keith Lillemoe, Boston, USA
- Nuh Rahbari, Ulm, Germany
- Ugo Boggi, Pisa, Italy
- Volkan Adsay, Istanbul, Turkey
11:30 - 11:50
Is every PanNET malignant?
Pelin Bagci, Lisbon, Portugal
11:50 - 12:10
Radiology of PanNETs
TBC
12:10 - 12:30
PanNET: Surgical Experience with 800 Patients
Thomas Hank, Heidelberg, Germany
12:30 - 12:50
PanNET Debate: Watch and Wait
Alessandro Zerbi, Milan, Italy
12:50 - 13:10
PanNET Debate: Surgery
Marta Sousa, Lisbon, Portugal
13:10 - 13:30
Rare Pancreatic Neoplasms
Christoph Berchtold, Heidelberg, Germany
09:15 - 09:30
Nanjing Campus 2025 - the new projects*
11:30 - 13:00
Seminar Room
Chairs:
- Yi Miao, Nanjing, China
- Kuirong Jiang, Nanjing, China
Mentors:
- Christoph Wolfgang, New York, USA
- Giovanni Marchegiani, Padova, Italy
- Jens Werner, Munich, Germany
- Jin He, Baltimore, USA
- Zipeng Lu, Nanjing, China
11:30 - 11:40
Prognostic Factors Based on Tumor Location (Head vs. Body/Tail) in the Era of Neoadjuvant Chemotherapy
Thomas Hank, Heidelberg, Germany
11:40 - 11:50
Postoperative Adjuvant Therapy and Optimization of Treatment Strategies in Pancreatic Cancer Patients Following Neoadjuvant Therapy
Yazhou Wang, Nanjing, China
11:50 - 12:00
Quality of Life Outcomes Following Conversion Therapy in BRPC and LAPC – Is It Worth It?
Saneya Pandrowala, Mumbai, India
12:00 - 12:10
Short- and Long-Term Outcomes of Minimally Invasive vs. Open Duodenum-Preserving Pancreatic Head Resection for Chronic Pancreatitis
Kongyuan Wei, Xi’an, China
12:10 - 12:20
Definition, Prediction, and Treatment of Post-Pancreatectomy Liver Injury
Nicola Canitano, Padova, Italy
12:20 - 12:30
Comparative Analysis of Post-Pancreatic Surgical Complications in Elderly vs. Younger Patients with Small Inactive Neuroendocrine Pancreatic Tumors
Ughur Aghamaliyev, Munich, Germany
12:30 - 12:40
Synthetic Allograft vs. Autologous Left Renal Vein for Venous Interposition – Proposal for a Randomized Controlled Multicenter Clinical Trial
Benedict Kinny-Koster, Heidelberg, Germany
12:40 - 12:50
Multicentric RCT on the Use of Anticoagulation After Venous Resection
Filipe Borges, Lisbon, Portugal
09:15 - 09:30
Lunch
13:30 - 14:20
09:15 - 09:30
Principles of Pancreatic Cancer Surgery
14:00 - 16:00
Champalimaud Auditorium
Chairs:
- Christopher Wolfgang, New York, USA
- Cristina Ferrone
- Helmut Friess
- Yi Miao, Nanjing, China
14:00 - 14:20
Surgery of peri-ampullary cancer
Richard Schulik, Denver, USA
14:20 - 14:40
Standards of oncological pancreatic head resection
Pierluigi Di Sebastiano, Pescara, Italy
14:40 - 15:00
Pancreatic Anastomosis
Waldemar Uhl, Bochum, Germany
15:00 - 15:20
Left Resection: RAMPS
TBC
15:20 - 15:40
Artery-first approaches
Kuirong Jiang, Nanjing, China
15:40 - 16:00
Total pancreatectomy
Miguel Fróis Borges, Lisbon, Portugal
09:15 - 09:30
PDAC Tumour microenvironment (1)
14:20 - 16:00
Botton Room
Chairs:
- Andrew Aguirre, Boston, USA
- Claus Jørgensen, Manchester, UK
- Giannicola Genovese, Houston, USA
- Mariano Barbacid, Madrid, Spain
14:20 - 14:40
Spatial proteomic maps of pancreatic cancer extend tumour subtype and microenvironment classifications
Hartland Jackson, Toronto, Canada
14:40 - 15:00
The Viral Basis of Pancreatic Cancer
David Ting, Boston, USA
15:00 - 15:20
Extracting mechanisms of cell cross talk in pancreatic cancer using big data
Nina Steele, Cincinnati, USA
15:20 - 15:40
Decoding the plasticity of stroma during pancreatic cancer progression and chemoresistance
Corinne Bousquet, Toulouse, France
15:40 - 16:00
Detecting and Preventing Lethal Pancreatic Cancer
Anirban Maitra, New York, USA
09:15 - 09:30
Coffee Break
16:00 - 16:30
09:15 - 09:30
Surgery for Borderline / LA PDAC
16:30 - 18:30
Champalimaud Auditorium
Chairs:
- Pauli Puolakkainen, Helsinki, Finland
- Phillipe Bachellier
- Richard Schulik, Colorado, USA
- Waldemar Uhl, Bochum, Germany
16:30 - 16:50
Multivisceral Resection
Helmut Friess, Munich, Germany
16:50 - 17:10
Triangle Operation
Vera Oliveira, Lisbon, Portugal
17:10 - 17:30
Peri-Arterial Divestment
Yi Miao, Nanjing, China
17:30 - 17:50
DP-CARs (Appleby) Operation
TBC
17:50 - 18:10
Venous Resection
Martin Schneider, Giessen, Germany
18:10 - 18:30
Arterial Resection
Markus Büchler, Lisbon, Portugal
09:15 - 09:30
Early detection, liquid biopsies and treatment for pancreatic cancer
16:30 - 18:30
Botton Room
Chairs:
- Carlos Carvalho
- Dirk Jäger
- Grainne O’Kane, Dublin, Ireland
- Jin He, Baltimore, USA
16:30 - 16:50
The Liver - Pancreatic Cancer Interaction
Heiner Wedemeyer, Hannover, Germany
16:50 - 17:10
Plasma whole genomes in pancreatic cancer
Faiyaz Notta, Toronto, Canada
17:10 - 17:30
PRECEDE Consortium
Dianne Simeone, California, USA
17:30 - 17:50
Epidemiology of pancreatic cancer
Nuria Malats, Madrid, Spain
17:50 - 18:10
PANcreatic Cancer Initial Detection via liquid biopsy
Matthias Löhr, Stockholm, Sweden
18:10 - 18:30
Revolutionised pancreatic cancer treatment
Beat Müller, Basel, Switzerland
09:15 - 09:30
Advanced Model Systems
09:00 – 11:00
Champalimaud Auditorium
Chairs:
- Channing Der, North Carolina, USA
- Giulia Biffi, Cambridge, UK
- Marina Pasca di Magliano, Michigan, USA
- William Hwang, Boston, USA
09:00 - 09:20
TBC
Scott Lowe, New York, USA
09:20 - 09:40
Defining and characterising the functional microenvironment of Pancreatic Cancer
Claus Jørgensen, Manchester, UK
09:40 - 10:00
Closing the circle: ex vivo and in vivo engineering of focal gene amplifications
Andrea Ventura, New York, USA
10:00 - 10:20
Spatial perturbation screens uncover immune-evasive tumor niches in pancreatic cancer
Chiara Falcomatà, New York, USA
10:20 – 10:40
Deep learning and integration of multi-omics for better understanding the early evolution of pancreatic cancer
Ashley Kiemen, Baltimore, USA
09:15 - 09:30
Session: IPMN
09:00 – 11:00
Botton Room
Chairs:
- Andre Mihaljevic
- Felix Nickel, Hamburg, Germany
- Yuichi Nagakawa, Tokyo, Japan
- Zipeng Lu, Nanjing, China
09:00 - 09:20
Pathology of IPMN
Volkan Adsay, Istanbul, Turkey
09:20 - 09:40
Genomic landscape
Anguraj Sadanandam, Lisbon, Portugal
09:40 - 10:00
EUS in IPMN
TBC
10:00 - 10:20
Principles of surgery for IPMN
Cristina Ferrone, Los Angeles, USA
10:20 - 10:40
Debate: Watch and Wait
Stefano Crippa, Milan, Italy
10:40 - 11:00
Debate: surgery
Ana João, Lisbon, Portugal
09:15 - 09:30
ISGPS session*
09:00 – 11:00
Seminar Room
09:15 - 09:30
Coffee Break
10:40 - 11:30
09:15 - 09:30
Robotic Pancreatic Surgery (1)
11:10 – 13:10
Champalimaud Auditorium
Chairs:
- Emanuel Vigia
- Kevin Conlon
- Michael Ghadimi, Berlin, Germany
- Safi Dokmak
11:10 - 11:30
Evidence based robotic surgery
Marc Besselink, Amsterdam, Netherlands
11:30 - 11:50
Pioneering robotic pancreatic
Herbert Zeh, Texas, USA
11:50 - 12:10
Robotic Surgery: Selection is Key
Nuh Rahbari, Ulm, Germany
12:10 - 12:30
Minimally Invasive Pancreatic Surgery
Ugo Boggi, Pisa, Italy
12:30 - 12:50
Robotic Pancreatic Head Resection
Felix Nickel, Hamburg, Germany
12:50 - 13:10
Organ Preserving Surgery
Jin He, Baltimore, USA
09:15 - 09:30
Advances in Pancreatic Cancer Oncology (1)
11:30 – 13:30
Bottom Room
Chairs:
- Götz Richter, Stuttgart, Germany
- Kim Reiss, Philadelphia, USA
- Paulo Costa
- Rong Liu
11:30 - 11:50
Neoadjuvant treatment
Carlos Carvalho, Lisbon, Portugal
11:50 - 12:10
Adjuvant treatment
John Neoptolemos, Heidelberg, Germany
12:10 - 12:30
Immunotherapy
Elke Jäger, Frankfurt, Germany
12:30 - 12:50
Systemic treatment opportunities and challenges
Philip Philip, Detroit, USA
12:50 - 13:10
GemPred trials: predicting Gemcitabine sensitivity
Jerome Cros, Paris, France
13:10 - 13:30
Update on PASS-1 trial: signature stratifications for treatment
Grainne O’Kane, Dublin, Ireland
09:15 - 09:30
Lunch
12:30 - 14:00
09:15 - 09:30
Robotic Pancreatic Surgery (2)
14:00 – 16:00
Champalimaud Auditorium
Chairs:
- Herbert Zeh
- Jürgen Weitz, Germany
- Mark Besselink
- Oliver Strobel
14:00 - 14:20
Robotic surgery: the learning curve
Amer Zureikat, Pittsburgh, USA
14:20 - 14:40
Techniques for anastomosis in robotic pancreatic surgery
Jiahong Dong, Beijing, China
14:40 - 15:00
Robotic Left Resection
Gil Gonçalves, Lisbon, Portugal
15:00 - 15:20
Robotic Triangle Operation
Yuichi Nagakawa, Tokyo, Japan
15:20 - 15:40
Complications after robotic pancreatic surgery
Rong Liu, Beijing, China
09:15 - 09:30
Advances in Pancreatic Cancer Oncology (2)
14:00 – 16:00
Bottom Room
Chairs:
- Ashok Saluja
- Elke Jäger
- John Neoptolemos, Heidelberg, Germany
- Philip Philip, Detroit, USA
14:00 - 14:20
Precision oncology and future treatments
TBC
14:20 - 14:40
PARP inhibitors and other maintenance therapies
Kim Reiss, Philadelphia, USA
14:40 - 15:00
Vaccination strategies
Dirk Jäger, Heidelberg, Germany
15:00 - 15:20
KRAS inhibitors
Christoph Springfeld, Heidelberg, Germany
15:20 - 15:40
Targeting IL1beta in combination with chemotherapy in advanced and localized pancreatic cancer
Paul Oberstein, New York
15:40 - 16:00
Therapeutic Strategies Targeting the TME in PDAC
Manuel Hidalgo, New York
09:15 - 09:30
Coffee break
16:00 - 16:30
09:15 - 09:30
Surgery of Advanced Pancreatic Cancer
16:30 – 18:30
Champalimaud Auditorium
Chairs:
- Amer Zureikat
- Beat Müller
- Markus Diener
- Pierluigi Di Sebastiano, Chieti, Italy
16:30 - 16:50
Resect the unresectable
Jürgen Weitz, Dresden, Germany
16:50 - 17:10
Arterial Reconstruction
Christopher Wolfgang, New York, USA
17:10 - 17:30
Multivascular Resection
Philippe Bachellier, Strasbourg, France
17:30 - 17:50
Portal vein occlusion: is reconstruction always necessary?
Jens Werner, Munich, Germany
17:50 - 18:10
Venous reconstruction techniques
Giovanni Marchegiani, Padova, Italy
18:10 - 18:30
Portal vein arterialization
Arianeb Mehrabi, Heidelberg, Germany
09:15 - 09:30
PDAC Tumour microenvironment (2)
16:30 - 18:10
Bottom Room
Chairs:
- Corinne Bousquet, Toulouse, France
- Hartland Jackson, Toronto, Canada
- Nina Steele, Cincinnati, USA
- Sophie Vasseur, Marseille, France
16:30 - 16:50
Establishment and temporal evolution of the pancreatic cancer microenvironment
Marina Pasca di Magliano, Michigan, USA
16:50 - 17:10
Tumor-Nerve Interactions in Pancreatic Cancer
William Hwang, Boston, USA
17:10 - 17:30
Roles of fibroblasts in pancreatic cancer metastasis and cachexia
Giulia Biffi, Cambridge, UK
17:30 - 17:50
Rag GTPase signaling in myeloid cells links nutrient overload with inflammation and PDAC
Alejo Efeyan, Madrid, Spain
17:50 - 18:10
Epigenetic reprogramming of pancreatic cancer to leverage anti-PD1 immunotherapy
Silvestre Vicent, Pamplona, Spain
09:15 - 09:30
APP (Associação Portuguesa do Pâncreas) Session*
16:30 - 17:00
Seminar Room

09:15 - 09:30
ESPAC session*
16:30 - 18:30
Seminar Room
Chairs:
- John Neoptolemos, Heidelberg, Germany
- Maximillian Reichert, Munich, Germany
16:30 - 16:35
ESPAC6 and 7 - Overview
Thomas Hank, Heidelberg, Germany
16:35 - 16:45
ESPAC6 - Update
Sabine Beck, Frankfurt, Germany
16:45 - 17:00
State of the Art - treatment of PDAC
Christoph Springfeld, Heidelberg, Germany
17:00 - 17:15
The ESPAC signature - quality control
Benedikt Bros, Heidelberg, Germany
17:15 - 17:30
Sample logistics
Tessa Peccerella, Heidelberg, Germany
17:30 - 17:40
The ESPAC translational programme - overview
Maximillian Reichert, Munich, Germany
17:40 - 17:50
ESPAC translational programme - Role of the tumor microenvironment
Barbara Grunwald, Essen, Germany
17:50 - 18:00
ESPAC translational programme - de - centralized organic workflow and co- cultura models
Daniel Ohlund, Umea, Sweden
18:00 - 18:10
ESPAC translational programme - surgical decision making
Guntac Uzunoglu, Hamburg, Germany
Welcome / Introduction
Advances in Pancreatic Cancer Treatment
Coffee Break
Advances in Pancreatic Cancer Treatment (Cont.)
Lunch Break
Cell plasticity and tumor heterogeneity
Developing Standards
International Study Group of Pancreatic Surgery (ISGPS)*
Coffee Break
Surgery vs wait and see: PanNET’s and IPMN
Surgery for Locally Advanced PDAC
09:15 - 09:30
Surgery of Oligometastatic Pancreatic Cancer
09:00 – 11:00
Champalimaud Auditorium
Chairs:
- Alessandro Zerbi, Milan, Italy
- Gil Gonçalves, Lisbon, Portugal
- Jiahong Dong, Beijing China
- Martin Schneider, Giessen, Germany
09:00 - 09:20
Indications for surgery
Markus Diener, Nürnberg, Germany
09:20 - 09:40
Standards of surgical treatment
Oliver Strobel, Vienna, Austria
09:40 - 10:00
Liver after lung or both?
Pauli Puolakkainen, Helsinki, Finland
10:00 - 10:20
The German RCT
Michael Ghadimi, Gottingen, Germany
10:20 - 10:40
Surgery of peritoneal disease
Mohammed Al-Saeedi, Heidelberg, Germany
10:40 - 11:00
TBC
09:15 - 09:30
Early Career Research Session
09:00 – 12:30
Bottom Room
Chairs:
- Alejo Efeyan, Madrid, Spain
- Andrea Ventura, New York, USA
- Ashley Kiemen, Baltimore, USA
- Chiara Falcomatà, New York, USA
- Direna Alonso-Curbelo, Madrid, Spain
- Rosalie Sears, Portland, USA
09:00 - 09:20
PCUK sponsored talk
Direna Alonso-Curbelo, Madrid, Spain
09:20 - 09:30
PCUK sponsored talk
TBC
09:30 - 09:40
PCUK sponsored talk
TBC
09:40 - 09:50
PCUK sponsored talk
TBC
09:50 - 10:00
Würth sponsored talk
TBC
10:00 - 10:10
Würth sponsored talk
TBC
10:10 - 10:20
Würth sponsored talk
TBC
10:20 - 10:30
Würth sponsored talk
TBC
10:30 - 10:40
Würth sponsored talk
TBC
10:40 - 10:50
Würth sponsored talk
TBC
10:50 - 11:00
Würth sponsored talk
TBC
09:15 - 09:30
Breakout Session: Young Pancreatologists Forum*
09:00 – 11:00
Seminar Room
Chairs:
- Thomas Hank, Heidelberg, Germany
- Filipe Borges, Lisbon, Portugal
09:15 - 09:30
Coffee Break
10:40 - 11:30
09:15 - 09:30
Surgery of Pancreatic Cancer
11:30 - 13:00
Bottom Room
Chairs:
- Arianeb Mehrabi, Heidelberg, Germany
- Luís Graça
- Mohammed Al-Saeedi, Heidelberg, Germany
- Robert Grützmann, Erlangen, Germany
11:30 - 11:50
Radicality of the triangle operation
Andre Mihajlevic, Tubingen, Germany
11:50 - 12:10
Portal Hypertension: bypass
Martin Loos, Heidelberg, Germany
12:10 - 12:30
Revolutionised pancreatic cancer treatment
Beat Müller, Basel, Switzerland
12:30 - 12:50
Drainage after pancreatic surgery
Kevin Conlon
12:50 - 13:10
TBC
09:15 - 09:30
Breakout Session: World Pancreas Forum - “The center effect”*
11:30 - 13:00
Seminar Room
Chairs:
- Ashok Saluja
- Christoph Wolfgang, New York, USA
- Markus Büchler, Lisbon, Portugal
- Yi Miao, Nanjing, China
The future of the WPF
Kasper Zgraggen, Bern, Switzerland
Caseload and experience
Jishu Wei, Nanjing, China
Clinical Trials
Benedict Kinny-Koster/Ingmar Rompen, New York, USA
The role of research to increase quality
Filipe Borges, Lisbon, Portugal
The learning curve
Adrian Billeter, Basel, Switzerland
Teaching the junior pancreatic surgeon
Saneya Pandrowala, Mumbai, India
Better quality with bigger teams
Ingmar Rompen, New York, USA
09:15 - 09:30
Recurrence of Pancreatic Cancer
11:30 - 13:30
Champalimaud Auditorium
Chairs:
- Christoph Berchtold, Heidelberg, Germany
- Giovanni Marchegiani, Padova, Italy
- Jens Werner, Munich, Germany
- Jerome Cros, Paris, France
11:30 - 11:50
Radiology of Recurrence
TBC
11:50 - 12:10
Predictive Factors of Early Recurrence
Elsa Francisco, Lisbon, Portugal
12:10 - 12:30
How to Prevent
Zipeng Lu, Nanjing, China
12:30 - 12:50
Radiotherapy
Inês Antunes, Lisbon, Portugal
12:50 - 13:10
Surgical Treatment
Robert Grützmann, Erlangen, Germany
13:10 - 13:30
Multivisceral and Complex Surgery
Safi Dokmak, Paris, France