Programme
09:15 - 09:30
Registration
16:00 - 18:30
Champalimaud Auditorium
Welcome / Introduction
Advances in Pancreatic Cancer Treatment
Coffee Break
Advances in Pancreatic Cancer Treatment (Cont.)
Lunch Break
Cell plasticity and tumor heterogeneity
Developing Standards
International Study Group of Pancreatic Surgery (ISGPS)*
Coffee Break
Surgery vs wait and see: PanNET’s and IPMN
Surgery for Locally Advanced PDAC
09:15 - 09:30
Registration
08:00 - 18:30
Champalimaud Auditorium & Botton-Champalimaud Pancreatic Cancer Centre
09:15 - 09:30
Welcome Introduction
08:30 - 09:00
Champalimaud Auditorium
- Leonor Beleza, Lisbon, Portugal
- João Silveira Botelho, Lisbon, Portugal
- Peter Bailey, Lisbon, Portugal
09:15 - 09:30
Borderline / Locally Advanced PDAC - Recent Standards of Diagnosis and Treatment
09:00 - 10:40
Champalimaud Auditorium
Chairs:
- Aaron Hansen, Brisbane, Australia
- Celso Matos, Lisbon, Portugal
- Grainne O’Kane, Lisbon, Ireland
- Laura Wood, Baltimore, USA
09:00 - 09:20
Clinical Trials: Overview
Eileen O’Reilly, New York, USA
09:20 - 09:40
KRAS Trials
Christoph Springfeld, Heidelberg, Germany
09:40 - 10:00
Triangle Operation Prevents Local Recurrence
Markus Büchler, Lisbon, Portugal
10:00 - 10:20
Imaging: CT, MRI and PET
Götz Richter, Lisbon, Portugal
10:20 - 10:40
Neoadjuvant Treatment Standards
Carlos Carvalho, Lisbon, Portugal
09:15 - 09:30
Borderline / Locally Advanced PDAC Surgery (1)
09:10 - 10:50
Botton Auditorium
Chairs:
- Cristina Ferrone, Los Angeles, USA
- Helmut Friess, Munich, Germany
- Michael Ghadimi, Göttingen, Germany
- Ugo Boggi, Rome, Italy
09:10 - 09:30
Biology to Define Resectability
Christopher Wolfgang, New York, USA
09:30 - 09:50
It’s all about Vascular Surgery
Thilo Hackert, Hamburg, Germany
09:50 - 10:10
The Role of Arterial Divestment
Yi Miao, Nanjing, China
10:10 - 10:30
How Much Neoadjuvant Chemotherapy?
Elena Rangelova, Gothenburg, Sweden
10:30 - 10:50
Artery First
Martin Loos, Heidelberg, Germany
09:15 - 09:30
Coffee Break
10:40 - 11:30
09:15 - 09:30
Poster Session 1
10:50 - 11:20
Champalimaud Auditorium Foyer
10:50 - 10:57
Targeting a Stress-Induced Surface Marker with a Bispecific T Cell Engager to Redirect Cytotoxicity Against Pancreatic Cancer and Its Stromal Microenvironment
Peter Kok-Ting Wan, Oxford, England
10:57 - 11:04
Collagen Stiffness Shapes the Stromal Microenvironment Architecture in Pancreatic Cancer in Vitro Models
Enrica Soprano, Lecce, Italy
11:04 - 11:11
A Fusogenic Axis in the Pancreatic Tumor Microenvironment: PSC–PDAC Hybrids as Drivers of Heterogeneity
Maria Iavazzo, Naples, Italy
11:11 - 11:18
The Nervous side of Cancer: Exploring Peripheral Signalling in Pancreatic Ductal Adenocarcinomas
Ariana Pina, Lisbon, Portugal
09:15 - 09:30
ISGPS Session
11:30 - 12:50
Botton Seminar Room
Chairs:
- Giovanni Marchegiani, Padova, Italy
- Shailesh Shrikhande, Mumbai, India
11:30 - 11:40
PPH
Filipe Borges, Lisbon, Portugal
11:40 - 11:50
Gastric Ischemia after DP-CAR - Proposal for Definition
Vera Oliveira, Lisbon, Portugal
11:50 - 12:00
Extent of Resection - Proposal for a Classification
Miguel Fróis Borges, Lisbon, Portugal
12:00 - 12:10
Post-Pancreatectomy Fluid Collection (PPFC): Definition and Grading from the International Study Group for Pancreatic Surgery (ISGPS)
Matteo De Pastena, Verona, Italy
12:10-12:20
Arterial Resection
Thilo Hackert, Hamburg, Germany
12:20 - 12:30
Oligometastatic Pancreatic Cancer Proposal for Definition
Cristina Ferrone, Los Angeles, USA
09:15 - 09:30
Translational / Oncology (1)
11:30 - 13:10
Champalimaud Auditorium
Chairs:
- Eileen O’Reilly, New York, USA
- Wungki Park, New York, USA
- Maxim Pimkin, Boston, USA
- Dieter Saur, Munich, Germany
11:30 - 11:50
Modelling Tumour Evolution
Roland Rad, München, Germany
11:50 - 12:10
LAPNet1 Clinical Trial
Gael Roth, Grenoble, France
12:10 - 12:30
PANOVA-3
Teresa Macarulla, Barcelona, Spain
12:30 - 12:50
Transcriptional States
Faiyaz Notta, New York, USA
12:50 - 13:10
A Spatially Resolved View of Subtypes: Biology and Translation
Barbara Grünwald, Essen, Germany
09:15 - 09:30
Borderline / Locally Advanced PDAC Surgery (2) - Minimally Invasive
11:30 - 13:10
Botton Auditorium
Chairs:
- Luís Graça, Lisbon, Portugal
- Yi Miao, Nanjing, China
- Götz Richter, Lisbon, Portugal
- George Zogopoulos, Montreal, Canada
11:30 - 11:50
The Chinese Approach
Baiyong Shen, Shanghai, China
11:50 - 12:10
The Qatari Approach
Mohammed Al-Saeedi, Doha, Qatar
12:10 - 12:30
Robotic Vascular Reconstruction
Ugo Boggi, Rome, Italy
12:30 - 12:50
The Korean Approach
Jin-Young Jang, Seoul, South Korea
12:50 - 13:10
Pancreatic Left Resection
Gil Gonçalves, Lisbon, Portugal
09:15 - 09:30
Lunch
13:10 - 14:00
09:15 - 09:30
Poster Session 2
13:20 - 13:45
Champalimaud Auditorium Foyer
13:22 - 13:29
Real-time Monitoring of Metabolic Adaptations in the PDAC Tumor-microenvironment via Advanced Noninvasive pH-sensor Platforms
Giulia Vanoni, Lecce, Italy
13:29 - 13:36
Targeting the MDK/PTN-ALK Axis Disrupts the Stroma-tumor Crosstalk and Boosts Antitumor Immunity
Beatriz Parejo, Zaragoza, Spain
13:36 - 13:43
Advanced Omics Platform at the Botton-Champalimaud Pancreatic Cancer Centre
Craig Nourse, Lisbon, Portugal
09:15 - 09:30
Early Career Researchers (1) - Würth
14:00 - 16:00
Botton Auditorium
Chairs:
- Nelson Dusetti, Marseille, France
- Federica Valsecchi, Brescia, Italy
- Jason Lee, Brisbane, Australia
14:00 - 14:20
Therapeutic Vaccination in Pancreatic Cancer: Dendritic Cells and Personalized Neoantigens
Dutch Representative: Casper van Eijck, Rotterdam, Netherlands
14:20 - 14:40
Amoeboid Escape from Premalignant Lesions Drives Early Metastatic Dissemination in Pancreatic Cancer
Italian Representative: Andrea Costamagna, Torino, Italy
14:40 - 15:00
From ER stress to PDAC: Impact of the CTRB2 Exon 6 Deletion Variant
Spanish Representative: Irene Felipe Abrio, Madrid, Spain
15:00 - 15:20
Pre-existing Intratumoral Programs Constrain Therapeutic Adaptation and Resistance Evolution in Pancreatic Ductal Adenocarcinoma
French Representative: Nicolas Fraunhoffer, Marseille, France
15:20 - 15:40
Integrated Multi-Platform Profiling Reveals KRAS-Dependent Spatial Organization of the Pancreatic Tumor Microenvironment
German Representative: Philipp Putze, Munich, Germany
15:40 - 16:00
Fibroblasts Durably Reprogram Pancreatic Tumor Cells to Enforce Immune Escape
Portuguese Representative (CF): Inês Ramos, Lisbon, Portugal
09:15 - 09:30
Borderline / Locally Advanced PDAC Surgery (3)
14:30 - 15:50
Champalimaud Auditorium
Chairs:
- Giovanni Marchegiani, Padova, Italy
- Charles Vollmer, Philadelphia, USA
- Christopher Wolfgang, New York, USA
- Shailesh Shrikhande, Mumbai, India
14:30 - 14:50
How to Avoid Local Recurrence
Marco Del Chiaro, Denver, USA
14:50 - 15:10
Venous Involvement: no Need for Neoadjuvant Treatment
Filipe Borges, Lisbon, Portugal
15:10 - 15:30
Multivisceral Resection
Beat Müller, Basel, Switzerland
15:30 - 15:50
Multivascular Resection
Philippe Bachellier, Strasbourg, France
09:15 - 09:30
Coffee Break
15:50 - 17:00
09:15 - 09:30
Poster Session 3
16:10 - 16:40
Botton Seminar Room
16:10 - 16:17
Integrated Optical pH Sensing in Patient-Derived 3D Pancreatic Cancer Models Enables Noninvasive Metabolic Monitoring and Prediction of Chemotherapeutic Efficacy
Anna Chiara Siciliano, Lecce, Italy
16:17 - 16:24
A Highly Plastic Immune Mimicking Stem-like Population Arises during Inflammation and Presents Resistance to Chemotherapy in Pancreatic Cancer Models
Juan Carlos López Gil, Madrid, Spain
16:24 - 16:31
Does Cell State Determine the Fitness Cost of ecDNA-Associated Genomic Instability?
Ricardo Blázquez, Lisbon, Portugal
16:31 - 16:38
The Botton-Champalimaud Pancreatic Cancer Center Biorepository
Greta Vainoraite, Lisbon, Portugal
09:15 - 09:30
Early Career Researchers (2)
16:50 - 19:10
Botton Auditorium
Chairs:
- Giulia Biffi, Cambridge, England
- Corinne Bousquet, Toulouse, France
- Arutha Kulasinghe, Brisbane, Australia
16:50 - 17:10
Trogocytosis-dependant Lipid Transfer between Pancreatic Fibroblasts and Cancer Cells: Role of the Phospholipide Scramblase ANO6
French Representative: Charline Ogier, Toulouse, France
17:10 - 17:30
Lung and Liver Metastasis are Distinct Clonal Events in Pancreatic Cancer
German Representative: Johanna Hölken, Essen, Germany
17:30-17:50
Leveraging Focused Ultrasound (FUS) to Improve Immunotherapy Responses in Pancreatic Cancer
PCUK Representative: Anita Fallah, Oxford, England
17:50 - 18:10
Pancreatic Cancer Risk at the Interface of Peripheral Innervation and Epithelial Regeneration
PCUK Representative: Rute Ferreira, London, England
18:10 - 18:30
Multi-stromal Organoid co-culture Modelling Reveals Epithelial-fibroblast Heterogeneity in Pancreatic Cancer and Pancreatitis
PCUK Representative: Wenlong Li, Cambridge, England
18:30 - 18:50
Mechanistic Insights into Irreversible Electroporation in Pancreatic Cancer: Integrating Ex Vivo Human Tissue Perfusion with Translational Models
PCUK Representative: Zainab Rai, London, England
18:50 - 19:10
CARES-AI: A Novel Checklist for Assessing Implementation Readiness in AI Applications – A Case Study in Pancreatic Cancer Early Detection and Diagnosis
PCUK Representative: Tianhui Zhu, London, England
09:15 - 09:30
Borderline / Locally Advanced PDAC Surgery (4)
17:00 - 18:40
Champalimaud Auditorium
Chairs:
- Marco Del Chiaro, Denver, USA
- Paulo Costa, Lisbon, Portugal
- Thilo Hackert, Hamburg, Germany
- Beat Müller, Basel, Switzerland
17:00 - 17:20
The Risk of Advanced Pancreatic Surgery
Charles Vollmer, Philadelphia, USA
17:20 - 17:40
Technical Options to Replace Vein and/or Artery
Shailesh Shrikhande, Mumbai, India
17:40 - 18:00
The TRIANGLE Operation
Vera Oliveira, Lisbon, Portugal
18:00 - 18:20
Deep Mesenteric Involvement
Giovanni Marchegianni, Padova, Italy
18:20 - 18:40
Arterial Resection vs Divestment
Robert Grützmann, Erlangen, Germany
Welcome / Introduction
Advances in Pancreatic Cancer Treatment
Coffee Break
Advances in Pancreatic Cancer Treatment (Cont.)
Lunch Break
Cell plasticity and tumor heterogeneity
Developing Standards
International Study Group of Pancreatic Surgery (ISGPS)*
Coffee Break
Surgery vs wait and see: PanNET’s and IPMN
Surgery for Locally Advanced PDAC
09:15 - 09:30
Registration
08:00 - 14:00
Champalimaud Auditorium & Botton-Champalimaud Pancreatic Cancer Centre
09:15 - 09:30
Metastatic PDAC - Oncology
09:00 - 11:00
Champalimaud Auditorium
Chairs:
- Carlos Carvalho, Lisbon, Portugal
- Teresa Macarulla, Barcelona, Spain
- Roland Rad, München, Germany
- Gael Roth, Grenoble, France
09:00 - 09:20
Vopimetostat + RAS(ON) Inhibitor Combination Therapy in Previously Treated Metastatic PDAC
Maxim Pimkin, Boston, USA
09:20 - 09:40
POLAR Trial
Wungki Park, New York, USA
09:40 - 10:00
Treatment for Germline BRCA-mutations in Metastatic Disease
Talia Golan, Ramat Gan, Israel
10:00 - 10:20
Population-based Surgery in Germany
René Mantke, Bradenburg, Germany
10:20 - 10:40
Approaching Tumor and Host Heterogeneity in Pancreatic Cancer
Jens Siveke, Essen, Germany
10:40 - 11:00
Delay in PDAC Management
Elsa Francisco, Lisbon, Portugal
09:15 - 09:30
Surgery for Metastatic PDAC (1)
09:00 - 10:40
Botton Auditorium
Chairs:
- Phillipe Bachellier, Strasbourg, France
- Nuno Bonito, Coimbra, Portugal
- Elena Rangelova, Gothenburg, Sweden
- Robert Grützmann, Erlangen, Germany
09:00 - 09:20
The German Multicenter Trial
Michael Ghadimi, Goettingen, Germany
09:20 - 09:40
How many Metastases to Resect?
Helmut Friess, Munich, Germany
09:40 - 10:00
The US Approach
Cristina Ferrone, Los Angeles, USA
10:00 - 10:20
The Role of HIPEC
Andreas Brandl, Frankfurt, Germany
10:20 - 10:40
Peritoneal Seeding
Tiago Bouça Machado, Porto, Portugal
09:15 - 09:30
Breakout Session: Young Pancreatologists Forum
09:00 - 10:45
Botton Seminar Room
Chairs:
- Filipe Borges, Lisbon, Portugal
- Thomas Hank, Heidelberg, Germany
- Greg Sacks, New York, USA
09:00 - 09:15
Arterial Disease in Pancreatic Cancer – Insights from Surgical Specimens
Benedict Kinny-Köster, New York, USA
09:15 - 09:30
Pushing the Limits of Resectability in Locally Advanced Pancreatic Cancer
Ingmar Rompen, Heidelberg, Germany
09:30 - 09:45
Delayed Bleeding after Pancreatic Surgery
Jishu Wei, Nanjing, China
09:45 - 10:00
SPLENDID: Spleen Preservationin Left Pancreatectomy for PDAC
Jony Van Hilst, Amsterdam, Netherlands
10:00 - 10:15
ANTIthrombotic Therapy in PANcreatIc Surgery with VasCular Resection: The ANTIPANIC Study
Alessio Marchetti, Padova, Italy
10:15 - 10:30
IPMN Cancer
Ana João, Lisbon, Portugal
10:30 - 10:45
Oncological Outcomes of Distal Pancreatectomy in Openvs. Minimally Invasive Resections for Pancreatic Cancer
Elias Gauer, Heidelberg, Germany
09:15 - 09:30
Coffee Break
10:40 - 11:30
09:15 - 09:30
Poster Session 4
11:00 - 11:30
Champalimaud Auditorium Foyer
11:00 - 11:07
Liquid Biopsy-based Biomarkers for Predicting Prognosis in Metastatic Pancreatic Cancer
Marta Toledano, Córdoba, Spain
11:07 - 11:14
IL17A Drives Tumor Microenvironment Remodelling and Pre-metastatic
Paula Ariadna Diez Villegas, Turin, Italy
11:14 - 11:21
TBC
Xu Zhou
11:21 - 11:28
CANCER MODELS PLATFORM: Clinically Anchored Models to Accelerate Pancreatic Cancer Research and Therapeutic Translation
Vanda Póvoa, Lisbon, Portugal
09:15 - 09:30
Keynote Lecture
11:30 - 12:00
Champalimaud Auditorium
Chair:
- Markus Büchler, Lisbon, Portugal
11:30 - 11:40
The Future of Research in Champalimaud Foundation
Otmar Wiestler, Lisbon, Portugal
09:15 - 09:30
Breakout Session:
World Pancreas Forum “Multicentric Collaborations for the Advance of Pancreatic Cancer Surgery”
12:00 - 13:00
Botton Seminar Room
Chairs:
- Yi Miao, Nanking, China
- Christopher Wolfgang, New York, USA
12:00 - 12:10
Major Advances from International Collaborations
Pierluigi Di Sebastiano, Chieti, Italy
12:10 - 12:20
International Collaborations for Training
Zipeng Lu, Nanjing, China
12:20 - 12:30
How to Fund Collaborative Research
Thomas Hank, Heidelberg, Germany
12:30 - 12:40
The Critical Side of Multicenter Registries
Marta Sousa, Lisbon, Portugal
12:40 - 12:50
The A-PHPBA Example
Shailesh Shrikhande, Mumbai, India
12:50 - 13:00
International Collaboratives: Measuring What Nobody Collects
Greg Sacks, New York, USA
09:15 - 09:30
Surgery for Metastatic PDAC (2)
12:00 - 13:40
Botton Auditorium
Chairs:
- Gil Gonçalves, Lisbon, Portugal
- Pierluigi Di Sebastiano, Chieti, Italy
- Baiyong Shen, Shanghai, China
12:00 - 12:20
Surgery in Stage IV
Miguel Fróis Borges, Lisbon, Portugal
12:20 - 12:40
Multivisceral Resections
Alexis Ulrich, Neuss, Germany
12:40 - 13:00
The Canadian Approach
George Zogopoulos, Montreal, Canada
13:00 - 13:20
Metachronous Metastasis Surgery
Nuh Rahbari, Ulm, Germany
13:20 - 13:40
Conversion Surgery
Thilo Welsch, Frankfurt, Germany
09:15 - 09:30
New Therapies and Metastasis
12:00 - 13:40
Champalimaud Auditorium
Chairs:
- Markus Büchler, Lisbon, Portugal
- Talia Golan, Ramat Gan, Israel
- Faiyaz Notta, Toronto, Canada
- Jens Siveke, Essen, Germany
12:00 - 12:20
Revolution Medicines' Strategic Vision for Pancreatic Cancer
Mauricio Monaco, Redwood City, USA
12:20 - 12:40
Molecular Signatures of Heterogeneous Response to Chemotherapy in Pancreatic Cancer
Laura Wood, Baltimore, USA
12:40 - 13:00
Metastatic Organotropism
Gulam Manji, New York, USA
13:00 - 13:20
High-Definition Profiling of Extra-pancreatic Dissemination
Peter Bailey, Lisbon, Portugal
13:20 - 13:40
Perineural Invasion in the TRIANGLE Region
Giuseppe Diaferia, Lisbon, Portugal
09:15 - 09:30
Lunch
13:30 - 14:30
09:15 - 09:30
Breakout Session:
Pancreatic Cancer Europe Research I “National Network Snapshots”
14:30 - 16:10
Botton Auditorium
Chairs:
- Peter Bailey, Lisbon, Portugal
- Vincenzo Corbo, Lisbon, Portugal
14:30 - 14:40
Introduction and Framing
Peter Bailey, Lisbon, Portugal
14:40 - 14:55
FRAP
Jérôme Cros, Paris, France
14:55 - 15:10
DPG
Maarten Bijlsma, Amsterdam, Netherlands
15:10 - 15:25
IPCC
Federica Valsecchi, Brescia, Italy
15:25 - 15:40
ALIPANC
Teresa Macarulla, Raquel Benitez Dorta, Barcelona, Spain
15:40 - 15:55
German Group
Jens Siveke, Paris, France
15:55 - 16:10
PCUK
Madina Kara, London, England
09:15 - 09:30
Breakout Session:
Pancreatic Cancer Europe Research II “Additional Perspectives”
15:55 - 17:00
Botton Auditorium
Chairs:
- Peter Bailey, Lisbon, Portugal
- Vincenzo Corbo, Lisbon, Portugal
15:55 - 16:10
Clinical Trials Network Perspective
Grainne O’Kane, Dublin, Ireland
16:10 - 16:25
International Translational Network Perspective
Faiyaz Notta, Toronto, Canada
16:25 - 16:40
International Translational Network Perspective
Aaron Hansen, Brisbane, Australia
16:40 - 17:00
General Discussion and Next Steps
Peter Bailey, PCE, Lisbon, Portugal



