Programme
09:15 - 09:30
Registration
16:00 - 18:30
Champalimaud Auditorium
09:15 - 09:30
Welcome Reception
17:00 - 18:30
Amphitheater
09:15 - 09:30
Registration
08:00 - 09:00
Champalimaud Auditorium & Botton-Champalimaud Pancreatic Centre
09:15 - 09:30
Welcome Introduction
09:00 – 09:15
Champalimaud Auditorium
- Markus Büchler, Lisbon, Portugal
09:15 - 09:30
Advances in Pancreatic Cancer Treatment
09:15 – 10:30
Champalimaud Auditorium
Chairs
- Yi Miao, Nanjing, China
- Francisco Paco Real, Madrid, Spain
- Ben Stanger, Philadelphia, USA
- Celso Matos, Lisbon, Portugal
09:15 - 09.40
The best oncological treatments being developed today
Eileen O’Reilly, New York, USA
09:40 - 10:05
Pancreatic cancer surgery in the 21st century
Markus Büchler, Lisbon, Portugal
10:05 - 10:30
Pancreatic cancer: the role of good clinical trials
John P. Neoptolemos, Heidelberg, Germany
09:15 - 09:30
Coffee Break
10:30 – 11:00
09:15 - 09:30
Advances in Pancreatic Cancer Treatment (Part 2)
11:00 – 12:15
Champalimaud Auditorium
Chairs
- Simon Barry, Cambridge, United Kingdom
- William L. Hwang, Boston, USA
- Christopher Wolfgang, New York, USA
- Carlos Carvalho, Lisbon, Portugal
11:00 - 11:25
Extra-chromosomal DNA: cancer’s dynamic circular genome
Paul Mischel, Stanford, USA
11:25 - 11:50
Molecular subtypes of PDAC
Peter Bailey, Lisbon, Portugal
11:50 - 12:15
Molecular pathogenesis of pancreatic cancer precursor lesions
Anirban Maitra, Houston, USA
09:15 - 09:30
Lunch Break
12:15 - 14:00
09:15 - 09:30
Cell Plasticity, Tumour Heterogeneity and Resistance to Therapy
14:00 - 16:00
Champalimaud Auditorium
Chairs
- Ramanuj Dasgupta, Singapore, Singapore
- Barbara Grünwald, Essen, Germany
- Gwen Lomberk, Wisconsin, USA
- Anirbarn Maitra, Houston, USA
14:00 - 14:25
Plasticity-induced resistance to immunotherapy
Ben Stanger, Philadelphia, USA
14:25 - 14:50
Understanding and targeting immunosuppression in PDAC
Dieter Saur, Munich, Germany
14:50 - 15:15
Molecular control of PDAC intratumour heterogeneity: from morphology to function
Gioacchino Natoli, Milan, Italy
15:15 - 15:40
Spatial elucidation of multicellular interactions and therapeutic resistance in PDAC at the single-cell resolution
William L. Hwang, Boston, USA
15:40 - 16:00
Mapping the organoid landscape to guide tumour state-targeting strategies
Maximilian Reichert, Munich, Germany
09:15 - 09:30
Developing Standards for Patient Management
14:00 - 15:30
Botton Auditorium
Chairs
- Marco Del Chiaro, Denver, USA
- Luis Graça, Oporto, Portugal
- Julia Mayerle, Munich, Germany
- Amer H. Zureikat, Pittsburgh, USA
14:00 - 14:15
Evidence based pancreatic surgery – what do we have, what’s new?
Markus Diener, Nuremberg, Germany
14:15 - 14:30
Pancreatic cancer trials – the patients' perspective
André Mihaljevic, Tübingen, Germany
14:30 - 14:45
Strategies and outcomes of advanced pancreatic cancers treatment
Michael Ghadimi, Göttingen, Germany
14:45 - 15:00
Implementation of a pre-habilitation program in pancreatic surgery
Mustapha Adham, Lyon, France
15:00 - 15:15
Evidence-based pathway for work-up of patients for pancreatic cancer surgery
Ajith Siriwardena, Manchester, United Kingdom
15:15 - 15:30
Pancreatic surgery in a high income, low(ish) volume country
David Cavallucci, Brisbane, Australia
International Study Group of Pancreatic Surgery (ISGPS)*
14:00 - 15:30
Botton Seminar Room
*Limited seats. First come, first served.
Chair
- Christos Dervenis, Athens, Greece
- Cristina Ferrone, Los Angeles, USA
- John P. Neoptolemos, Heidelberg, Germany
- Jens Werner, Munich, Germany
14:00 - 14:10
A simple anatomical classification for locally advanced pancreatic cancer by the ISGPS
Christopher Wolfgang, New York, USA
14:10 - 14:20
Interobserver variability for the ISGPS-defined complications after pancreatoduodenectomy: an international cross-sectional multicenter study
Marc Besselink, Amsterdam, Netherlands
14:20 - 14:40
Clinical and economic validation of the international study group definition of post-pancreatectomy acute pancreatitis
Giovanni Marchegiani, Padua, Italy
14:40 – 14:50
Complexity and competency grading to guide patient selection for robotic and laparoscopic minimally-invasive pancreatoduodenectomy: An International Study Group for Pancreatic Surgery (ISGPS) consensus
Shailesh Shrikhande, Mumbai, India
14:50 - 15:00
Definitions of arterial divestment and arterial resection procedures in pancreatic surgery – Consensus of the ISGPS
Thilo Hackert, Hamburg, Germany
15:00 - 15:10
Post-pancreatectomy hemorrhage – proposal for a classification update
Ana João, Lisbon, Portugal
15:10 - 15:20
Classification ISGPS: surgical treatment of metastasized pancreatic cancer
Cristina Ferrone, Los Angeles, USA
Jens Werner, Munich, Germany
15:20 - 15:30
Classification of postpancreatectomy diarrhea
Oliver Strobel, Vienna, Austria
09:15 - 09:30
Coffee Break
15:30 - 16:30
09:15 - 09:30
Surgery vs Wait and See: PanNET’s and IPMN
16:30 - 17:45
Botton Auditorium
Chairs
- Christoph Berchtold, Heidelberg, Germany
- Cristina Ferrone, Los Angeles, USA
- Peter Malfertheiner, Magdeburg, Germany
- Miguel Fróis Borges, Lisbon, Portugal
16:30 - 16:45
Challenges in defining “malignancy” in PanNETs and IPMNs
Volkan Adsay, Istanbul, Turkey
16:45 - 17:00
PanNET: watch and wait
Massimo Falconi, Milan, Italy
17:00 - 17:15
PanNET: surgery
Filipe Borges, Lisbon, Portugal
17:15 - 17:30
Surgery for cystic tumours of the pancreas
Christoph Michalski, Heidelberg, Germany
17:30 - 17:45
Stereotypes about italians: eating pasta, drinking espresso and keep watching IPMNs of the pancreas
Giovanni Marchegiani, Padua, Italy
09:15 - 09:30
Surgery for Locally Advanced Pancreatic Cancer
16:30 - 18:15
Champalimaud Auditorium
Chairs
- Massimo Falconi, Milan, Italy
- Shailesh Shrikhande, Mumbai, India
- Oliver Strobel, Vienna, Austria
- Christoph Michalski, Heidelberg, Germany
16:30 - 16:45
Peri-arterial divestment for LA-PDAC
Yi Miao, Nanjing, China
16:45 - 17:00
Surgery of borderline pancreatic cancer
Christopher Wolfgang, New York, USA
17:00 - 17:15
Strategy for complex venous reconstruction
Jürgen Weitz, Dresden, Germany
17:15 - 17:30
Extended pancreatic left resection
Mohammed Al-Saeedi, Heidelberg, Germany
17:30 - 17:45
Surgical strategies for the treatment of locally advanced pancreatic cancer
Marco Del Chiaro, Denver, USA
17:45 - 18:00
Portal vein arterialization
Arianeb Mehrabi, Heidelberg, Germany
18:00 - 18:15
Surgical treatment for LA-PDAC after NACT
Jiang Kuirong, Nanjing, China
09:15 - 09:30
Multimodal Treatment (1)
16:30 - 18:00
Botton Seminar Room
Chairs
- Thilo Hackert, Hamburg, Germany
- Giovanni Marchegiani, Padua, Italy
- Eileen O’Reilly, New York, USA
- Carlo Greco, Lisbon, Portugal
16:30 - 16:45
Biomarker developmentfor early detection – current status
Julia Mayerle, Munich, Germany
16:45 - 17:00
Vaccine and cell-based therapy strategies
Dirk Jäger, Heidelberg, Germany
17:00 - 17:15
New ESMO guidelines
Dirk Arnold, Hamburg, Germany
17:15 - 17:30
Radiotherapy in 2024: how to fill a half-empty glass?
Susannah Ellsworth, Pittsburgh, USA
17:30 - 17:45
Targeted precision: unlocking the power of SBRT in oligometastatic pancreatic cancer treatment
Maria Inês Antunes, Lisbon, Portugal
17:45 - 18:00
Is liver metastasis still contraindication for pancreas resection?
Dejan Radenkovic, Belgrade, Serbia
Welcome / Introduction
Advances in Pancreatic Cancer Treatment
Coffee Break
Advances in Pancreatic Cancer Treatment (Cont.)
Lunch Break
Cell plasticity and tumor heterogeneity
Developing Standards
International Study Group of Pancreatic Surgery (ISGPS)*
Coffee Break
Surgery vs wait and see: PanNET’s and IPMN
Surgery for Locally Advanced PDAC
09:15 - 09:30
Registration
08:00 - 09:00
Champalimaud Auditorium & Botton-Champalimaud Pancreatic Centre
09:15 - 09:30
Multimodal Treatment (2)
09:00 – 10:30
Champalimaud Auditorium
Chairs
- Dirk Arnold, Hamburg, Germany
- Michael Ghadimi, Göttingen, Germany
- Martin Loos, Heidelberg, Germany
- Christoph Springfeld, Heidelberg, Germany
09:00 - 09:15
What we still don’t know about neoadjuvant treatment
Carlos Carvalho, Lisbon, Portugal
09:15 - 09:30
Lessons from the Alliance trials
Cristina Ferrone, Los Angeles, USA
09:30 - 09:45
Lessons from the PREOPANC trials
Marc Besselink, Amsterdam, Netherlands
09:45 – 10:00
Plea for adjuvant therapy or surgical recommendations of the german living guideline
Waldemar Uhl, Bochum, Germany
10:00 – 10:15
Conversion surgery for advanced pancreatic cancer – do new guidelines help us?
Thilo Hackert, Hamburg, Germany
10:15 - 10:30
Oligometastatic pancreatic cancer: time for resection?
Oliver Strobel, Vienna, Austria
09:15 - 09:30
Diagnostics and Early Detection
09:00 – 10:00
Botton Auditorium
Chairs
- Paulo Matos Costa, Lisbon, Portugal
- Beat Müller, Basel, Switzerland
- Ashok Saluja, Miami, USA
- Craig Nourse, Lisbon, Portugal
09:00 - 09:15
State of the art radiology of PDAC
Celso Matos, Lisbon, Portugal
09:15 - 09:30
Staging for pancreatic cancer: 2024 and beyond
Matthew Katz, Houston, USA
09:30 - 09:45
Interventional radiology of PDAC
Goetz Richter, Stuttgart, Germany
09:45 - 10:00
Endoscopy and pancreatic cancer
Jacques Devière, Brussels, Belgium
European Study Group for Pancreatic Cancer (ESPAC)*
09:00 – 11:00
Botton Seminar Room
*Limited seats. First come, first served.
Chairs
- Peter Bailey, Lisbon, Portugal
- John P. Neoptolemos, Heidelberg, Germany
09:00 - 09:15
Current status of ESPAC6
Sabine Beck, Frankfurt, Germany
09:15 - 09:30
The ESPAC and other transcriptomic treatment specific signatures
Benedikt Brors, Heidelberg, Germany
09:30 - 09:45
Induction chemotherapy for LAD PDAC – the ESPAC7 design
Christoph Springfeld, Heidelberg, Germany
09:45- 10:00
Surgery for LAD PDAC after induction chemotherapy – do’s and don’ts in ESPAC7
Thilo Hackert, Hamburg, Germany
10:00 - 10:15
Organoids in the ESPAC translation programme
Max Reichert, Munich, Germany
10:15 - 11:00
Free discussion
09:15 - 09:30
Coffee Break
10:15 - 11:00
09:15 - 09:30
Multimodal Treatment (3)
11:00 - 12:30
Champalimaud Auditorium
Chairs
- Dirk Jäger, Heidelberg, Germany
- Jorge Paulino, Lisbon, Portugal
- Alain Sauvanet, Paris, France
- Ajith Siriwardena, Manchester, United Kingdom
11:00 - 11:15
Tackling new treatments for pancreatic cancer: the PanCAN know your tumour and precision promise experiences
Lynn Matrisian, Washington, USA
11:15 - 11:30
Multimodal integrated classification for precise management of pancreatic cancer
Baiyong Shen, Shanghai, China
11:30 - 11:45
Autophagy inhibition for patients with resectable and locally advanced PDAC
Michael Lotze, Pittsburgh, USA
11:45 - 12:00
Targeted therapy in KRAS-wildtype pancreatic cancer patients
Christoph Springfeld, Heidelberg, Germany
12:00 - 12:15
Next-generation predictive biomarkers
Rémy Nicolle, Paris, France
12:15 - 12:30
Systemic therapy challenges and opportunities
Philip Philip, Detroit, USA
09:15 - 09:30
Diagnostics and Early Detection (Part 2)
11:00 - 12:30
Botton Auditorium
Chairs
- Volkan Adsay, Istanbul, Turkey
- Jin He, Baltimore, USA
- Lynn Matrisian, Washington, USA
- Matthew Katz, Houston, USA
11:00 - 11:15
Pancreatic cancer research: “when an apple a day is not enough”
Ashok Saluja, Miami, USA
11:15 - 11:30
Identification of germline mutations
William Greenhalf, Liverpool, United Kingdom
11:30 - 11:45
Personalised therapies according to germline mutations
Daniel Palmer, Liverpool, United Kingdom
11:45 - 12:00
Dissecting the complexity of the atopy-PDAC association
Nuria Malats, Madrid, Spain
12:00 - 12:15
The role of helicobacter pylori in PDAC
Peter Malfertheiner, Munich, Germany
12:15 - 12:30
Preventing pancreatic cancer
Matthias Löhr, Stockholm, Sweden
09:15 - 09:30
Lunch Break
12:30 - 13:30
09:15 - 09:30
Targeted Therapies and PDAC Genomes
13:30 - 16:00
Champalimaud Auditorium
Chairs
- Vincenzo Bronte, Padua, Italy
- Benedikt Brors, Heidelberg, Germany
- Paul Mischel, Stanford, USA
- Raul Urrutia, Milwaukee, USA
13:30 - 13:55
Understanding & taming pancreas cancer
Ronald DePinho, Houston, USA
13:55 - 14:20
Molecular origins of pancreatic cancer phenotypes
Faiyaz Notta, Toronto, Canada
14:20 - 14:45
Leveraging genetic mouse models for precision prevention
Francisco Paco Real, Madrid, Spain
14:45 - 15:10
ecDNA amplifications drive intra-tumour heterogeneity and phenotypic adaptation
Vincenzo Corbo, Verona, Italy
15:10 - 15:35
Harnessing writer’s block – targeting epigenomic pathways
Gwen Lomberk, Wisconsin, USA
15:35- 16:00
Characterizing the influence of metabolic remodeling on immune microenvironment
Anguraj Sadanandam, London, United Kingdom
09:15 - 09:30
Pancreatic Cancer Surgery
14:00 - 15:30
Botton Auditorium
Chairs
- Saxon Connor, Canterbury, New Zealand
- Markus Diener, Nuremberg, Germany
- Baiyong Shen, Shanghai, China
- Kaspar Z'graggen, Zurich, Switzerland
14:00 - 14:15
Standard resection for cancer
Helmut Friess, Munich, Germany
14:15 - 14:30
Surgery after neoadjuvant treatment
Jens Werner, Munich, Germany
14:30 - 14:45
Evolution of 2400 pancreatic resections at Tata Memorial Centre: lessons learnt
Shailesh Shrikhande, Mumbai, India
14:45 – 15:00
How to prevent local recurrence after pancreatic cancer surgery
Vera Oliveira, Lisbon, Portugal
15:00 - 15:15
Technique of pancreatic anastomosis
Pierluigi Di Sebastiano, Chieti-Pescara, Italy
15:15 - 15:30
Technical innovations to reduce pancreatic fistula rate during pancreatic resections
Dezső Kelemen, Pecs, Hungary
09:15 - 09:30
Coffee Break
15:30 - 16:30
09:15 - 09:30
Tumour Microenvironment
16:30 - 18:30
Champalimaud Auditorium
Chairs
- Vincenzo Corbo, Verona, Italy
- Gioacchino Natoli, Milan, Italy
- Anguraj Sadanandam, London, United Kingdom
- Dieter Saur, Munich, Germany
16:30 - 16:50
3D multi-omic cellular maps and self-propelled CAR T cells to infiltrate pancreatic tumours
Denis Wirtz, Baltimore, USA
16:50 - 17:10
Heterogeneity and self-organization in PDAC
Barbara Grünwald, Essen, Germany
17:10 - 17:30
The immune-excluded environment in PDAC
Vincenzo Bronte, Padua, Italy
17:30 - 17:50
Aged mouse models of PDAC better recapitulate patient tumour biology and highlight age-specific vulnerabilities
Giulia Biffi, Cambridge, United Kingdom
17:50 - 18:10
3D multi-omic analysis of human pancreatic tissue
Laura Wood, Baltimore, USA
18:10 - 18:30
Neuroimmune regulation
Henrique Veiga-Fernandes, Lisbon, Portugal
09:15 - 09:30
Minimally Invasive Treatment
16:30 - 18:00
Botton Auditorium
Chairs
- Marc Besselink, Amsterdam, Netherlands
- Christos Dervenis, Athens, Greece
- Johanna Laukkarinen, Helsinki, Finland
- Waldemar Uhl, Bochum, Germany
16:30 - 16:45
Robotic pancreatic surgery
Jiahong Dong, Beijing, China
16:45 - 17:00
The practice of robotic pancreatoduodenectomy after the EUROPA and DIPLOMA2 trials
Jin He, Baltimore, USA
17:00 - 17:15
Robotic surgery for advanced pancreatic cancer: precise anatomical pancreatoduodenectomy with mesenteric approach
Yuichi Nagakawa, Tokyo, Japan
17:15 - 17:30
Feasibility, proficiency, and mastery in robotic pancreatoduodenectomy
Ugo Boggi, Pisa, Italy
17:30 - 17:45
Lessons learned after nearly 1000 robotic pancreatoduodenectomies at a single center
Amer H. Zureikat, Pittsburgh, USA
17:45 - 18:00
Robotic pacreatic surgery – really a game changer?
Beat Müller, Basel, Switzerland
09:15 - 09:30
Conference Dinner
19h30
Convento do Beato
Neoadjuvant and Induction Therapies
Diagnostics and Early Detection
European Study Group for Pancreatic Cancer (ESPAC)*
Coffee Break
Neoadjuvant and Induction Therapies (Cont.)
Diagnostics and Early Detection (Cont.)
Lunch Break
Targeted therapies and PDAC genomes
Pancreatic Cancer Surgery
Coffee Break
PDAC tumour microenvironment
Minimally Invasive Treatment
09:15 - 09:30
Registration
08:00 - 09:00
Champalimaud Auditorium & Botton-Champalimaud Pancreatic Centre
09:15 - 09:30
Complex Pancreatic Cancer Surgery
09:00 – 10:30
Champalimaud Auditorium
Chairs
- Jiahong Don, Beijing, China
- Helmut Friess, Munich, Germany
- Arianeb Mehrabi, Heidelberg, Germany
- Guilherme Tralhão, Coimbra, Portugal
09:00 - 09:15
Factors influencing mortality following pancreatic surgery
René Mantke, Brandenburg, Germany
09:15 - 09:30
Portal vein replacement
Gil Gonçalves, Lisbon, Portugal
09:30 - 09:45
Pediatric pancreatic cancer surgery
Christoph Berchtold, Heidelberg, Germany
09:45 - 10:00
Distal pancreatectomy: should the spleen be always resected?
Alain Sauvanet, Paris, France
10:00 - 10:15
LA-PDAC – the Heidelberg experience
Martin Loos, Heidelberg, Germany
10:15 - 10:30
New surgical techniques in pancreatic surgery
Martin Schneider, Heidelberg, Germany
09:15 - 09:30
Tumours in Time and Space
09:00 – 10:30
Botton Auditorium
Chairs
- Giulia Biffi, Cambridge, United Kingdom
- Carlos Minutti, Lisbon, Portugal
- Henrique Veiga-Fernandes, Lisbon, Portugal
- Laura Wood, Baltimore, USA
09:00 - 09:15
Onco-fibrotherapy in pancreatic cancer: can the cancer wound heal?
Daniel Öhlund, Umeå, Sweden
09:15 - 09:30
Interrogating tumour evolution “in time and space”
Ramanuj Dasgupta, Singapore, Singapore
09:30 - 09:45
Cancer stem cells
Adriana Sánchez-Danés, Lisbon, Portugal
09:45 - 10:00
Cancer dormancy and immunity
Ana Luísa Correia, Lisbon, Portugal
10:00 - 10:15
Cancer and memory T-cells
Klaas van Gisbergen, Lisbon, Portugal
10:15 - 10:30
Liquid biopsy for the clinical management of pancreatic cancer
Jörg Hoheisel, Heidelberg, Germany
World Pancreas Forum: “Pancreatic Cancer Centres”
09:00 – 10:15
Botton Seminar Room
*Limited seats. First come, first served.
Chairs
- Yi Miao, Nanjing, China
- Shailesh Shrikhande, Mumbai, India
- Christopher Wolfgang, New York, USA
- Kaspar Z’graggen, Zurich, Switzerland
09:00 - 09:15
Jiang Kuirong, Nanjing, China
09:15 - 09:30
Beat Müller, Basel, Switzerland
09:30 - 09:45
Marta Sousa, Lisbon, Portugal
09:45 - 10:00
Christoph Michalski, Heidelberg, Germany
10:00 - 10:15
Christopher Wolfgang, New York, USA
09:15 - 09:30
Coffee Break
10:30 - 11:00
09:15 - 09:30
Vision of the Champalimaud Foundation
11:00 - 11:30
Champalimaud Auditorium
Presenter
- João Silveira Botelho, Vice-President of the Champalimaud Foundation, Lisbon, Portugal
09:15 - 09:30
Clinical Applications for Molecular Subtypes
11:30 - 13:30
Botton Auditorium
Chairs
- Frank Bergmann, Heidelberg, Germany
- Rémy Nicolle, Paris, France
- Faiyaz Notta, Toronto, Canada
- Daniel Öhlund, Umeå, Sweden
11:30 - 11:50
Integrated profiling in advanced PDAC: lessons from the COMPASS and PASS-01 trials
Grainne O’Kane, Dublin, Ireland
11:50 - 12:10
Applying spatial multiomics to therapeutic discovery
Simon Barry, Cambridge, United Kingdom
12:10 - 12:30
Focal amplification in cancer genomes: origin, structure, and function
Vineet Bafna, California, USA
12:30 - 12:50
Mechanisms shaping genome complexity and evolution
Jose Espejo Valle-Inclán, Lisbon, Portugal
12:50 - 13:10
Epigenetic subtypes
Raul Urrutia, Milwaukee, USA
13:10 - 13:30
Predictive models based on machine learning from transcriptomics data
Benedikt Brors, Heidelberg, Germany
09:15 - 09:30
Complication Management in Pancreatic Surgery
11:30 - 13:00
Champalimaud Auditorium
Chairs
- Mustapha Adham, Lyon, France
- Jiang Kuirong, Nanjing, China
- Yuichi Nagakawa, Tokyo, Japan
- Gil Gonçalves, Lisbon, Portugal
11:30 - 11:45
Postoperative pancreatic inflammation: mechanisms, and how to detect and prevent
Johanna Laukkarinen, Tampere, Finland
11:45 - 12:00
Post pancreatectomy acute pancreatitis
Saxon Connor, Canterbury, New Zealand
12:00 - 12:15
Interventional treatment
Hugo Rio-Tinto, Lisbon, Portugal
12:15 - 12:30
Endoscopic treatment of complications
Ricardo Rio-Tinto, Lisbon, Portugal
12:30 - 12:45
Reconstruction after pancreatic resection: evidence, delayed gastric emptying and functional consequences
Kaspar Z’graggen, Bern, Switzerland
12:45 - 13:00
Management of diabetes and maldigestion
Friedrich Hoppichler, Vienna, Austria